Stress in infancy ‘dramatically alters’ body’s organs

Solving mysteries: Researchers Dr Mohsen Seifi, left, and Adina Gibbard, who is now studying for her PhD

Scientists have found evidence suggesting emotional stress in infancy has significantly more far-reaching effects on the body than previously thought and could even result in disease later in life.

Psychological stress in infancy dramatically changed the amount of an important class of proteins, called GABAA receptors, which in turn may alter the workings of the heart, lungs, kidneys and bladder.

It was already known that changes in the amounts of GABAA receptors causes some brain disorders, but researchers at the University of Portsmouth are the first to show that stress can also alter their expression in other organs as well.

The research team in the School of Pharmacy and Biomedical Sciences studied the way GABAA receptors behave in secondary organs in mice which had first been exposed to stress.

The study provides hope that drugs targeting these receptors can now be developed to treat a range of medical conditions, from hypertension to asthma, and from diabetes to inflammatory bowel diseases.

The study is published in Frontiers in Molecular Neuroscience.

Microscopic image of the GABAA receptor in the mouse intestine

One of the researchers, Dr Jerome Swinny, said: “GABAA receptors were known to control brain activity and served as important targets for many drugs used in modern medicine to treat brain disorders, such as epilepsy, anxiety as well as inducing surgical anaesthesia.

“We were surprised to find these proteins were also found to be expressed so widely beyond the brain.

“The dramatic stress-induced changes in the amounts of GABAA receptor compared to what one normally finds is intriguing. It will alter organ function and, we suggest, will contribute to diseases of the organs.”

The research, was led by senior research associate Dr Mohsen Seifi, together with Ethan Everington and Adina Gibbard who were MSc and BSc students, respectively, at the time, in the University’s School of Pharmacy and Biomedical Sciences.

The research was carried out in the laboratory of Dr Swinny, a reader in neuropharmacology and one of the authors.

He said: “It has long been known that childhood adversity, such as neglect or abuse, confers a vulnerability to developing a range of medical conditions later in life, including mental illnesses such as anxiety, and cardiovascular or metabolic disorders.

The GABAA receptor CREDIT: Wikipedia

“However, precisely how such emotional challenges impact on the normal functioning of different organs within our body remains elusive, which stops the development of effective drug therapies.”

The human central nervous system is designed to withstand stress, he said, and a certain amount of stress allows humans to adapt and survive in an ever changing environment. The problems begin when exposure to stress is constant.

“A sustained threat is detrimental to our survival. The nervous system of an infant is not mature enough to be able to cope with prolonged exposure to the chemicals which mediate our stress response. As a result, such experiences often confer a vulnerability to changes to the normal development of their body and mind.

“We know a lot about these proteins in the brain and that’s enabled us to develop drugs for associated conditions such as anxiety. We hope that this new understanding of stress and these receptors can eventually be applied to other parts of the body, to treat a wide range of disorders from hypertension, to diabetes, to an upset tummy.”

Ethan is now studying medicine at Nottingham University and Adina is enrolled for a PhD in Alzheimer’s disease, funded by the Alzheimer’s Society, in Dr Swinny’s lab.

UoP News © 2018 All Rights Reserved